Synthesis of optically active .ALPHA.-alkyl or .ALPHA.-aryl acids from L-.ALPHA.-amino acids by the use of organocopper reagents.

Synthesis of optically active amino acids from alpha-keto acids with Escherichia coli cells expressing heterologous genes.

We describe a simple method for enzymatic synthesis of L and D amino acids from alpha-keto acids with Escherichia coli cells which express heterologous genes. L-amino acids were produced with thermostable L-amino acid dehydrogenase and formate dehydrogenase (FDH) from alpha-keto acids and ammonium formate with only an intracellular pool of NAD+ for the regeneration of NADH. We constructed plasm...

One Pot Synthesis of Alpha-Aminonitrile and Alpha-Amino Acid From Schiff Bases

Addition of Potassium cyanide to a mixture of Schiff base and lithium perchlorate afforded a-aminonitriles in high yields. Addition of potassium cyanide to a methanolic solution of Schiff base and phosphoric acid afforded a-aminonitriles. When the reaction mixture was refluxed it gave a-amino acids in high yields.

Antigenicity of Polypeptides (poly Alpha Amino Acids)

It has been shown that the polymers GLA5, GLT, GLA40, and GLAT are antigenic in human beings. Both immediate skin reactions and delayed (cellular) reactions were observed. The antibody produced reacted well in the precipitin reaction, agglutinated antigen coated tanned sheep cells, was less effective in inducing PCA reactions, and failed to sensitize guinea pigs for passive systemic anaphylaxis...

Alpha helix propensity of amino acids.

one pot synthesis of alpha-aminonitrile and alpha-amino acid from schiff bases

addition of potassium cyanide to a mixture of schiff base and lithium perchlorate afforded a-aminonitriles in high yields. addition of potassium cyanide to a methanolic solution of schiff base and phosphoric acid afforded a-aminonitriles. when the reaction mixture was refluxed it gave a-amino acids in high yields.